Elizabeth Mitchell

Mitchell had a recurring role as psychiatrist Dr. Kim Legaspi, the first lesbian lover of Dr. Kerry Weaver (Laura Innes) during the 2000–01 season of TV series ER. She also played Angelina Jolie's hairdresser/lover in the movie Gia.

In March 2009, Entertainment Weekly reported that Mitchell had been cast in new ABC pilot for V, its remake of the classic science fiction television miniseries. Although ABC and Warner Bros. officials told the magazine she was only cast as a guest star, the announcement led to speculation and concern that Mitchell's character would be killed off at the end of Lost's fifth season, which ended on a cliffhanger that left the fate of her character unknown. Mitchell was later named the lead actress on V in an ABC press release and various sources reported that she would guest-star in Lost's sixth, final season.Mitchell's character was killed off in the sixth season premiere, but returned for the two-part series finale for which she received a nomination for the Primetime Emmy Award for Outstanding Guest Actress in a Drama Series.

The show V was picked up for a second season, which premiered on January 4, 2011 but was not picked up for a third season. Mitchell had a guest starring role on Law & Order: Special Victims Unit in 2011 where she played June Frye. Mitchell starred in the film, Answers to Nothing in 2011, where she played Kate. On June 30, 2012, NBC announced that Elizabeth had joined the cast of the upcoming series Revolution as Rachel Matheson, replacing actress Andrea Roth whom Mitchell worked with for one episode on Lost. The series premiered on September 17, 2012.

Actress Elizabeth Banks who was born Elizabeth Irene Mitchell, changed her name to avoid confusion with Mitchell.